About Neuronopathy
Diseases Diseases

About Neuronopathy

Published at 04/03/2012 19:46:28


About Neuronopathy

The term neuronopathy was introduce to describe a neurological syndrome characterized by primary damage of the nerve cell body.

Neuronopathy it an inherited neuromuscular disease that causes progressive muscle wasting weakness in the limbs without any sensory impairment. It is also a functional disturbance or pathological change in the peripheral nervous system complication of disease. Disorder of the peripheral nervous system.

Paraneoplastic origin is one of the causes of sensory neuronopathy.The main clinical complains at the onset are pain and paresthesias with asymmetric distribution tha involve arms rather than legs and later pain is replaced by numbness, limb ataxia, and psedoathetotic movements of the hands.

Subacute sensory neuronopathy is a paraneoplastic syndrome, which occurs mostly in lung, breast, ovarian malignancies and lymphoma. Sensory neuronopathy as a preceding sign of recurrence in colon adnocarcinoma has not previously been reported.

Axonal degeneration represents one of the earliest pathological features in motor neuron diseases.It remains unclear however whether axonal dying back is triggered in the axon itself of whether it is a consequence of degenerative changes originating in the cell body.


About Neuronopathy

The account presented in this provides a detailed historical review of the development of thought relating to the causes of neuromuscular disease.

A state of the art period to 1850-1890 were a period of parallel and interdependent advances in both normal neuro-anatomy and neurophysiology, and diseases recognized as variation from such norms. In 1891 was described the first case of childhood neuronopaty recognized as such, and with this development was ushered in the modern era of clinical differential diagnosis of childhood neuromuscular disease.


About Neuronopathy

Symptoms of neuronopathy are weak extensor muscles of big toe,muscle weakness in lower legs, paralysis of lower leg muscles, wasting of lower leg muscles, paralysis of lower arm muscles , wasting of lower arm muscles, reduced reflexes in legs and absent reflexes in legs.

Diabetic neuropathy is a complication of diabetes causing damage to the nerves that allow you to feel sensations such as pain. The areas of the body most commonly affected by diabetic peripheral neuropathy are the feet and legs. Nerves damage in the feet can result in a loss of foot sensation, increasing ones risk of foot problems.

Tips and comments

In paraneoplastic neurological syndromes associated with neuronal damage, sensory neuronopathy rarely improves with treatment. The best chance to at least stabilize the syndrome is to induce a complete response of the tumor. Immunotherapy rarely is effective but a trial with intravenous immunoglobulins, steroids or plasmapeheresis in indicated because there are a few patient who improved.

The continual further refining of an exact diagnosis is the only way in which a realistic prognosis can be forecast, correct genetic counseling can be offered, and if the condition is treatable optima therapy can be introduced.

In the case of subacute sensory neuronopathy without an obvious underlying etiological factor, an occult malignity should always be researched in clinical practice.

Signs of terminal axonal reinnervation, such as motor axon reflex, may be observed in axonal neuronopathies, whereas only collateral reinnervation occurs in motor neuronopathies. Sensory axonopathies are usually characterized by clinical and electrophysiological findings that are axon length-dependent, by the course of the disorder that is most often chronic, and by possible reversibility.


Most Recent Articles

  • What Deseases Are Caused By Low Vitamin Intake
    People who have low vitamin intake may cause often deseases and low immune system. Vitamins and minerals are usually comes from the food we eat such as green leafy vegetables, fruits an...
  • How To Protect Yourself From Emerging Infectious Disease
    Many people are not aware of how serious infectious diseases can be. Some people are not even aware of the fact that these infectious diseases can be morbid and end in a tragic death. So if ...
  • How To Prevent Atrophy Diseases
    Disease belonging to any class of the diseases can be prevented only by proper care and by strictly following the precautionary measures advised by the physician or doctor. Most of the disea...
  • Information About Mermaids
    Mermaid syndrome is a congenital disorder. A fetus develops this disease when it is still in the mother's womb. This syndrome is quite rare and only one baby out of 80,000 babies gets this. ...
  • Tips on how to take care of immunocompromised family member
    An immunocompromised person is someone who lacks the ability to immune against the infectious disease; or in simple words it is a person who cannot resist the seasonal infectious diseases th...
  • How To Protect Yourself From Coccidiosis
    Coccidiosis is considered to be one of the most fatal protozoan diseases in the world. This disease has gained so much ground because it shows mild symptoms and disappear or they appear with...
  • Preventative Measures For Sexually Transmitted Deasease
    There are many preventive measures that one can take to avoid getting a sexually transmitted deasease. Most of the deasease are transmitted through sex but not all of them. The biggest group...
  • How To Treat Scrapies in Sheep And Goats
    Scrapie is a terminal, degenerative disease that affects the central nervous system of sheep and goats. Scrapie belongs to the transmissible spongiform encephalopathies family of diseases. T...
  • How To Find Books About Diseases
    If you want to know more about the different common diseases that can occur in daily life then you will be happy to know that there are books that can tell you more about it. Books have alwa...
  • How To Prevent Imha
    Your pets too can acquire disease like you. Some of these diseases may be those common ones or those that are serious in nature. Like people, dogs also have their own immune system. Our immu...
  • What Are The Causes Of Alcoholic Diseases
    If you are an alcohol drinker then you must have heard about the many things people say about alcohol and how it affects your body. You must have heard or read about the many health issues t...
  • What Are The Common Conditions Affecting The Bloodstream
    In our generation today, where sedentary living is common, presents a real concern over our health. With the advent of fast food, we expose ourselves to the danger of not eating nutrit...
  • How To Protect Yourself From Shingles Diseases
    Shingles or herpes zoster is a devastating come back of chickenpox caused by the varicella zoster virus or VZV. Once the person has had chickenpox, VZV stays in the body.  It does not c...
  • Health And Fitness Diseases Of Digestive System
     It is common knowledge that for our body to work properly and effectively it needs the much needed nutrients and nourishments. For us to be able to get our body properly nourished, you...
  • How To Treat Small Cell Lung Cancer
    Cancer is the cause of many deaths around the world. This has also become the most feared disease of the world. There are many organs of the body that are affected by cancer. Lung cancer is ...