Diseases Diseases

What Information Can Omim Give About Genetic Disease

MIM is now OMIM

Doctors never stop reading and learning to know the latest update of disorders and fatal diseases, by doing so, they use a special type of database called MIM. MIM stands for Mendelian Inheritance in Man which was first made by Johns Hopkins, and was periodically published in 1966. When it became available online since 1987, it was called Online Mendelian Inheritance in Man (OMIM), it is a collection of information on genetic disorders and genes. Online Mendelian Inheritance in Man was intended for primarily use by physicians, professionals related with genetic disorders, by genetic researchers, and by advance students in science and medicine.

OMIM as the new generation

OMIM database can be search by MIM numbers, disorder or gene name, symbols or plain English. Each OMIM entry is assigned with a unique six-digit numbers and symbols, without it before an entry number means that the mode of inheritance has not been proven or that the distinction between this locus and another is uncertain.

Update log is a tool that allows a quick check of the latest additions and changes to OMIM. Restrictions on Use is being implemented to inform the user that OMIM is copyrighted by the Johns Hopkins University and is made available to the general public subject to certain restrictions.

Topics related to OMIM

Online Mendelian Inheritance in Man (OMIM) can give information about any known genetic diseases, causes or where it came from, laboratory test or examination, explanation on every detail that a doctor or professional or advance medicine students might need. The genetic diseases included are:

1. Single gene inheritance – often called Mendelian or monogenic inheritance which causes by changes or mutation that occurs in DNA sequence of single gene. Examples are sickle cell anemia, Huntington’s disease and hemochromatosis.
2. Multifactorial inheritance – often called complex or polygenic inheritance. This causes by a combination of environmental factors and mutation in multiple genes such as cancer, diabetes and high blood.
3. Chromosome abnormalities – these results due to abnormalities in chromosome number and structure. Some examples are Down syndrome, turner syndrome and cat cry syndrome.
4. Mitochondrial inheritance – is a type of genetic disorder caused by mutations in the nonchromosomal DNA of mitochondria (a small round, rod-like, organelles that are involved in cellular respiration found in cytoplasm of plants and animals). Example of which is an eye disease called Leber’s hereditary optic atrophy; another example is a type of epilepsy called MERRF (Myoclonus Epilepsy with Ragged Red Fibers).

OMIM and the people who uses it

Online Mendelian Inheritance in Man (OMIM) is very complicated database that the medicine people care about because it helps them understand and know deeper a certain disease without going to other countries or enrolling to a certain Collegiate or University. Although, it would be best to learn them literally, emergency situation is a big help. So, as for normal users, this type of database are shared to you, you must learn how to respect the preciosity of Online Mendelian Inheritance in Man (OMIM), to preserve the history and shared knowledge of the medicine people, doctors and other medicine professional and non-professional.

By Felix Go, published at 02/08/2012
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